Immune Signature Projects

• Project 1 : https://immunespace.org/is1.url

Title: Multi-cohort analysis reveals baseline transcriptional predictors of influenza vaccination responses

Condition studied: Reaction to influenza vaccination.

Number of participants: 533

Brief description: Identification of human host genes and gene sets that predict a strong immune response to the influenza vaccine in cohorts of individuals under 35 years old and over 60 years old across time and place using baseline (day 0) data.

Objective: Identification of human host genes and gene sets that predict a strong immune response to the influenza vaccine in cohorts of individuals under 35 years old and over 60 years old across time and place. For details, please see the following manuscript: Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses. Sci Immunol (2017). PMID 28842433.

• Project 2 : https://immunespace.org/is2.url

Title: HIPC-II Immune Signatures Data Resource and Analysis (IS2)

Brief description: The HIPC Immune Signatures Data Resource provides integrated host response data from human vaccination studies involving multiple vaccines. Pre-vaccination and temporal response profiles are analyzed to identify unique and common signatures, including those associated with differential antibody responses.

Objective 1: Create a compendium of standardized systems vaccinology datasets to support comparative analyses. For details please see the following manuscript: The Immune Signatures data resource, a compendium of systems vaccinology datasets. Sci Data 9, 635 (2022). PMID 36266291.

Objective 2: Identify a common pre-vaccination signature and mechanisms that predict the immune response across a wide variety of vaccines. For details, please see the following manuscript: Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. Nat Immunol (2022). PMID 36316476.

Objective 3: Identify common signatures and mechanisms associated with the temporal response or predictive of vaccine immunogenicity. For details, please see the following manuscript: Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nat Immunol (2022). PMID 36316475.